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- ISSN: 1570-1794
- E-ISSN: 1875-6271
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Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies
- Source: Current Organic Synthesis, Volume 18, Issue 8, Dec 2021, p. 761 - 789
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- 01 Dec 2021
Abstract
Azaarenes are unique scaffolds that are frequently found in pharmaceuticals. Herein we have summarized the recent synthetic available methods in C–H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation, alkylation via different methods, alkenylation, oxidative functionalization, and cyclization of the methylazaarenes will be discussed in this review.
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