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2000
Volume 22, Issue 5
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Introduction

An efficient procedure was reported for the synthesis of novel hybrid dithiazoles and thiazoles , in good yields, by applying hydrazonyl chlorides with thiocarbohydrazone derivatives and .

Methods

The thiazole derivatives were evaluated for their antimicrobial and antioxidant activities.

Results

According to the results, thiazoles revealed marked potency as antimicrobial and antioxidant agents. Thus, 's DPPH radical scavenging activity was excellent (38.19±0.33 and 14.37±0.4) at concentrations of 2.0 and 1.0 mg/mL, respectively. In addition, compound exhibited activity against all bacterial strains tested, as evidenced by inhibition zones measuring that ranged from 8.5±0.43 mm for to 16.5±0.43 mm for .

Conclusion

The MIC results showed that compound was effective against , , , , and at concentrations of 1.0, 1.0, 2.0, 1.0, and 1.0 mg/mL, respectively. Furthermore, molecular docking has shown lower binding energy with different types of interactions at the active sites of Dihydropteroate synthase, Sortase A, LasR, and penicillin-binding protein pockets, indicating that these compounds could inhibit the enzyme and cause promising antimicrobial effects.

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2025-07-26

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Synthesis, Molecular Docking, Antimicrobial, and Antioxidant Evaluation of Novel Dithiazole and Thiazole Derivatives
Curr. Org. Synth. 22, 662 (2025); https://doi.org/10.2174/0115701794334314241212114056
/content/journals/cos/10.2174/0115701794334314241212114056
/content/journals/cos/10.2174/0115701794334314241212114056
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  • Article Type:     Research Article
Keyword(s): ADME; antimicrobial activity; antioxidant activity; docking; hydrazonyl chlorides; Synthesis; thiazole

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