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image of Synthesis and Antitumor Activities of Novel 5-amino-3-(halophenyl)-1-phenyl-1H-pyrazole-4-carbonitriles

Abstract

In this work, a series of novel 3-(halophenyl)-1-phenyl-1H-pyrazole moieties have been synthesized. Their structures were characterized by IR, NMR, and MS spectroscopy, and the corresponding antitumor properties were also studied.

Objectives

This study aimed to synthesize a series of new 3-(halophenyl)-1-phenyl-1H-pyrazole moieties and survey the antitumor properties of these compounds.

Materials and Methods

3-(halophenyl)-1-phenyl-1H-pyrazoles () were prepared by reaction of phenyl hydrazine () with different halogen aromatic aldehydes and malononitrile () in CHOH and piperidine. The reaction took place under microwave irradiation settings for two minutes at140°C.

Results

Three human cancer cell lines were used as test subjects for compounds . Three cell lines from mammals (a cell line for human cervical cancer), (a cell line for human breast cancer), and (a cell line for human prostate cancer), all with 5-fluorouracil as the standard reference drug were used.

Conclusion

A series of novel 3-(halophenyl)-1-phenyl-1H-pyrazoles were synthesized in this work. All substances had their anticancer properties assessed.

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2024-05-06
2025-03-01

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/content/journals/cos/10.2174/0115701794259226231023091306
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Synthesis and Antitumor Activities of Novel 5-amino-3-(halophenyl)-1-phenyl-1H-pyrazole-4-carbonitriles
Bentham Science Publishers ; https://doi.org/10.2174/0115701794259226231023091306
/content/journals/cos/10.2174/0115701794259226231023091306
/content/journals/cos/10.2174/0115701794259226231023091306
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  • Article Type:     Research Article
Keywords: haloaromatic aldehydes ; phenyl hydrazine ; Microwave ; antitumor activities ; malononitrile ; spectroscopy

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