Current Organic Chemistry - Volume 26, Issue 4, 2022

Substituted thiazoles are widely known as natural products, approved drugs, and a number of synthetic compounds as bioactive agents. Due to the worth of this heterocycle nucleus, a large number of synthetic methodologies have been reported over the years to synthesize its derivatives. In this perspective, recent advances in the synthesis of thiazole compounds by using domino/cascade and multicomponent approaches ha Read More

Photoredox catalysis as a powerful strategy for the activation of small molecules requires the use of reactants which are suitable to undergo single-electron transfer with the formation of radicals. In this perspective, we highlight the unique ability of organoboronic acid derivatives to form radicals under photoredox catalysis conditions with particular emphasis placed on the methods of activation of B-C bonds. Key to facilita Read More

Gelsemine is a remarkable indole alkaloid isolated from the medicinal plant Gelsemium elegans (Carolina or yellow jasmine) and demonstrates effectiveness in alleviating cognitive impairment, suggesting it could treat Alzheimer's disease. Gelsemine comprises seven adjoining chiral carbon centres and hexacyclic cage structures, making it an oddly difficult synthetic target. The unique structure and potential bio-pharmacolog Read More

Sulfinic acids, sodium sulfinates, and sulfonyl hydrazides are stable, inexpensive, and readily available building blocks, which have been recently utilized as synthons to access various heterocyclic motifs via radical sulfonylation and cyclization. This review systematically summarizes the radical cyclization cascades and discusses their mechanisms. Moreover, it also discusses multi-component reactions, rearrangements, cycloadd Read More

Organic azides are placed in the interphase between chemistry, biology, medicine, and materials science. Their uses in peptide chemistry, combinatorial chemistry, and the synthesis of heterocycles are extensively explored. In this review, the focus is placed on the azidoreductive cyclization of azides and detailed its significant insights. The wide-ranging literature for synthesizing various heterocycles, employing che Read More

The last decade has witnessed a remarkable progress in the field of nanoscience and nanotechnology. Nanoparticles have been extensively used in diverse areas, including medicine, sensor, and catalysis. The easy accessibility of nanoparticles (NPs) with different shapes, sizes and compositions has inspired researchers to investigate their applications in catalysis. Recently, magnetic nanoparticles, such as iron-based nanoparticles Read More

Background: Phosphine-free Pd-catalytic platforms, i) combination with chitosan- Schiff base (CS-Py/Pd), ii) immobilized on chitosan-Schiff base (CS-Py@Pd), and iii) anchored to modified carbon nanotube support (CNT@CS-Py@Pd), Methods: They were evaluated regarding a novel pathway for the cross-coupling reaction of arylboronic acids with acid chlorides. Results: The CS-Py@Pd platform had the highest catalytic efficiency Read More