Current Organic Chemistry - Volume 26, Issue 20, 2022

In today’s world, aryl halides have attracted our attention toward the amination reactions catalyzed by palladium. In this review article, there are some selected developments in the field of catalysis, and the Buchwald-Hartwig amination reaction is one of them. It is a common and highly efficient method reported for forming dibenzodiazepines. The readily accessible precursors and ammonia undergo cross-coupling reactions in the presence of a palladium catalyst; after that, the intermediate immediately undergoes intramolecular condensation to give the desired dibenzodiazepines in one step. Due to the structural characteristics of these compounds, the potential for diversification - principally for functional group incorporation - is immense. New and advanced technologies are also employed to form these medicinally important molecules and are reviewed here. Our purpose is to inform the researchers about recent advances in this protocol for the C-N bond formation, especially used for synthesizing dibenzodiazepines.

In this review, we have focused our attention on Pd-catalyzed amination and arylation reactions for the construction of various benzodiazepine scaffolds. It includes numerous types of synthetic strategies like C-H arylation, Pd-catalyzed carbonylation, and Buchwald Hartwig coupling. To synthesize different functionalized benzodiazepines, the domino processes as intra- or intermolecular reactions are developed as an eco-friendly and effective tool. Benzodiazepines exhibit several biological activities and play a valuable role in medicinal and pharmaceutical chemistry. This review article mainly focuses on synthesizing a 1,4- benzodiazepine nucleus fused with 5-membered carbo- and heterocycles in the presence of palladium catalysts.

Recently, the application of green chemistry for the formation of potential bioactive heterocyclic moieties has turned out to be the key area of research for organic chemists due to the growing concern over environmental issues. Therefore, the development of nonhazardous synthetic protocols gained the particular attention of synthetic chemists as a frontier task in the present scenario. Nowadays, microbial infections have been haunting human civilization since prehistoric times, resulting in many deaths worldwide. Cancer is a fatal and dreadful disease without any appropriate cure, thus threatening humanity in both the developing and developed worlds. Therefore, there is a critical requirement for the design and synthesis of new classes of compounds to circumvent these diseases. Heterocycles are unique precursors for the synthesis of various pharmaceuticals and agrochemicals, particularly those possessing N- or O- moieties. The methods to prepare heterocycles are of great importance in synthesizing organic compounds, especially the heterocycles found in natural products. The synthesis of nitrogen and oxygen-containing heterocycles viz. Coumarins, dihydropyrimidinones, imidazoles, isoxazoles, and benzimidazoles represent attractive and demanding work for chemists as these molecules have found extensive applications in several fields, such as materials science, analytical chemistry and most importantly in, medicinal chemistry. In this review paper, we focus on the synthetic strategy to prepare these types of heterocyclic compounds by green methods and discuss their various biological applications.

Human population is increasing at an alarming rate which indirectly imposes pressure on agriculture and food supply. However, crop production is reduced by pathogenic infections which have engrossed the attention of chemists and agriculturists to develop newer agrochemicals with improved characteristics. Quinoline, one of the nitrogen-containing heterocyclic compound act as a privileged scaffold in the designing of highly efficient drugs due to their chemical and biological diversity. It has gained significant attention for several years due to its broad spectrum of biological activities such as anti-malarial, anti-microbial, anti-cancer, anti-inflammatory, anti-plasmodial, and anti-protozoal etc. The depiction of varied biological activities of quinoline impelled us to outlook the progress of synthesis and agrochemical potential of numerous quinoline derivatives with well-known and typical examples from 2015 to 2021. The review focuses on the advancement in the synthesis of quinoline derivatives and their agrochemical potential. This review revealed that abundant work has been done in order to synthesize quinoline derivatives and were evaluated for their agrochemical potential using different methods. The information given in this article may be helpful to the researchers to analyze the already reported studies and explore new compounds for the development of efficient agrochemicals.