Current Organic Chemistry - Volume 21, Issue 3, 2017

Conjugate addition reactions of organometallic compounds to electron-poor olefins is a versatile synthetic methodology for the formation of new carbon–carbon bonds. However, a careful control of the regioselectivity of the process is needed because of the presence of two electrophilic sites in the activated olefin. This issue is often overcome by employing "soft" nucleophiles such as organocopper and organozinc reagents, be Read More

Glycosylation of small biologically active molecules, either of natural or synthetic origin, has a profound impact on their solubility, stability, and bioactivity, making glycoconjugates attractive compounds as therapeutic agents or nutraceuticals. A large proportion of secondary metabolites, including flavonoids, occur in plants as glycosides, which adds to the molecular diversity that is much valued in medicinal chemistry studi Read More

Organic mechanochromic luminescent materials are under extensive research because of their potential applications in sensors and security. An ideal mechanochromic material should comprise high fluorescent quantum yield in the solid state, significant fluorescent change after mechanical stimulus and high sensitivity to mechanical force, however, few materials reported till now meet all the requisites due to that our limited Read More

The oxime ester moiety exists in a large number of bioactive compounds by a wide range of activities, including antibacterial, antifungal, anti-inflammatory, antioxidant, anti-diabetes and cytotoxic activities. They are also showed interesting insecticidal activities. Furthermore, these compounds are important starting materials in the preparation of photosensitive compositions. Oxime esters are one of the most import Read More

Recently, the development of nanotechnology and nanomaterial has promoted extremely the application of drug delivery systems in the biomedical field. However, the drug delivery into the central nervous system (CNS) is limited because the existence of the blood brain barrier (BBB). Therefore, to develop the efficient drug delivery systems (DDS) for crossing the BBB into the lesions is necessary. The holistic DDS, which successful Read More