Current Organic Chemistry - Volume 21, Issue 15, 2017

Background: Polyheterocyclic compounds have numerous applications in different fields ranging from medicinal chemistry to material science. Cascade reactions represent the most direct and efficient method to obtain polyheterocyclic molecules with functional diversity and increased complexity. Moreover, novel polycyclic systems can be generated which can possess interesting properties such as biological activity or l Read More

Background: Cascade reactions, as an attractive branch of organic chemistry, have been the subject of intense research in the recent years. In these reactions numerous transformations occur in a single sequence, and the subsequent reactions are formed as a consequence of the functionality of the previous step. Cascade reactions are environmentally benign processes due to their one-pot procedure which accord Read More

Background: Cascade reactions are well-known as powerful process to design complex molecular structures from simple and cheap starting compounds by using two or more reactions in a single consecutive transformation. These reactions, forming a number of bonds by one operation, are useful for the creation of polycyclic and spirocyclic compounds. Thus, cascade reactions play important role in modern organic che Read More

Background: The design and performing of cascade reactions is a challenging but stimulating and interesting facet of organic synthesis, yet one that can convey conspicuous novelty, efficiency as well as elegance and sophistication to synthetic approaches. On the other hand, isocyanides are well-recognized as privileged synthons in the synthesis of a wide range of heterocycles. Objective: In this review, we try to illustrate the Read More

Background: Heterocyclic scaffolds widely occur in natural products and pharmaceutical molecules and because of their broad biological activities, the synthesis of such frameworks with diverse approaches is one of the most attractive fields in modern organic chemistry. Recently, cascade reactions catalyzed by transition metals made astounding advances in the synthesis of heterocyclic compounds for their step economy. Read More