Current Organic Chemistry - Volume 21, Issue 14, 2017

Polyhedral oligomeric silsesquioxanes (POSS) are perfect three-dimensional elemental building blocks that can be used for construction of diverse inorganic/organic hybrid materials. Well-defined inorganic frameworks, tailor-made physicochemical properties and symmetric distribution of organic groups make the hybrid organo-silica compounds ideal nano-fillers for polymer composites. Understanding the phenomena dire Read More

In the recent decades, N-heterocycles are widely used as versatile scaffolds for the development of biologically active compounds and considered as one of the privileged structures. Among the various N-heterocycles, benzodiazines, a series of bicyclic heterocycles in which benzene rings are fused with 6-membered heterocycles containing two nitrogens are especially interesting, due to their structural conciseness and usefuln Read More

3-(Monosubstituted)alkylideneoxindoles as one major part of the oxindoles are involved in many essential biologically active compounds, like as self-germination and tyrosine kinase inhibitors. They have been extensively used as starting materials for the synthesis of a large number of different heterocycles. The aim of this review is to give an overview of diverse methodologies that have been developed for the construction of 3- Read More

Background: The 3-substituted 3-hydroxyisoindolinone motif is common to a variety of compounds with potent biological activities. In recent years, they have also been increasingly used as substrates in various asymmetric transformations. Current methods for their preparation either do not tolerate wide range of functional groups, or yield 3-hydroxyisoindolinones as N-substituted products, which makes them inapplicable as s Read More