Current Organic Chemistry - Volume 21, Issue 13, 2017

This review updates recent applications of asymmetric aziridination, azirination, thiirination, epoxidation, and cyclopropanation in the total synthesis of biologically active compounds, including natural products, using chiral substrates or chiral catalysts, covering the literature since 2000. The interest towards these synthetic methodologies of chiral three-membered rings has increased in the last decade, dictated either by the Read More

Oligo- and polysaccharides have complicated structures because of the structurally different monosaccharide units and differences in stereo- and regioarrangements of glycosidic bonds. As enzymatic reactions proceed in highly regio- and stereo-controlled manner, these are well accepted as a powerful tool for the precise synthesis of well-defined oligo- and polysaccharides. For example, α-glucan phosphorylase has increasingly Read More

In recent years, chiral guanidines have attracted considerable interest in organic synthesis because of their unique structural features and strongly basic properties. Compounds belonging to this structural class can act as not only Brønsted bases but also through a hydrogen bond activation mode either of the nucleophile or of the electrophile, and have consequently been widely used in asymmetric organic catalysis, deliverin Read More

Background and Objective: Continuing our researches in the field of heterocyclic chemistry, the study on the chemical properties of compounds simultaneously containing different heterocycles such as fused thieno[2,3-b]pyridines, fused triazoles has been carried out. Moreover, their possible antimicrobial activity against some gram-positive and gram-negative bacilli strains has been evaluated. Methods: Starting from the hydr Read More