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Stereoselective formation of six-membered carbacycles with biological and pharmaceutical relevance is one of the prime research areas in modern organic synthesis. Various innovative synthetic protocols involving asymmetric C-C bond forming reactions have been developed and exploited widely. The present review attempts to elaborate the original contributions and recent advancements made in this field for the stereoselective synthesis of a diverse array of asymmetric sixmembered carbacyclic compounds employing very simple and/or advanced organocatalytic domino reactions.