Organic/Inorganic Hybrid Functionalized Magnetic Nanoparticles for High Throughput Biomolecular Separation

Synthesis of the functionalized silica-coated magnetic nanoparticles (Si-MNPs) was achieved with organic/inorganic hybrids and approached for high throughput biomolecular separation. To increase the reactivity between biomolecules and Si-MNPs, organic/ inorganic hybrid functionalization has been obtained through the coupling of organosilanes, having various organic residues, with free sianol groups of the silica surfaces. This review gives an overview of the preparation, properties, and current applications of the materials in the areas of immunomagnetic and enzymatic separations as well as biomolecule separations, with the main focus being on Si- MNPs. The organic/inorganic hybrid functionalized Si-MNPs allow the development of sophisticated nanoscale separation systems for bioanalytical, biosensor-based, clinical and environmental applications.