Organocatalytic Application of Axially Dissymmetric BINOLs and their Conversion into Binaphthyl Phosphoric Acids

3,3'-disubstituted axially dissymmetric BINOLS, owing to their lower acidity have limited organocatalytic applications in stereoselective transformations. Nevertheless, they serve as potent and immediate precursors to much stronger Bronsted acids e.g. binaphthyl phosphoric acids. The review lists some suitably substituted and sterically demanding BINOLS, their use in organic transformations and possibility to convert them into stronger Bronsted acids as more effective organocatalysts.