Nanohydroxyapatite Microspheres as a Biocompatible and Recoverable Catalyst for Synthesis of Carbon -Phosphorous Bond Formation

Nanohydroxyapatite microsphere (HAp) as an environmentally benign and biocompatible material is found to be efficient catalyst for the synthesis of α-hydroxy and α-amino phosphonates derived from carbonyl compounds. This heterogeneous catalyst does not require aqueous workup, additionally catalyst can be simply recovered and recycled.