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2000
Volume 13, Issue 5
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

With this part of the special issue on “Synthetic Organic Chemistry”, inserted in the Volume 13, Number 5, March 2009 of Current Organic Chemistry, my second activity, as Guest Editor, comes to an end. It has indeed been a pleasure to be involved with this work including three reviews which deal with the cycloaddition methodology for biologically active heterocycles, recent developments on rotaxane-based shuttles and an update until 2008 on regeneration of carbonyl compounds from the corresponding oximes. I hope that this special issue will be appreciated by chemists who deal with the organic synthesis. The first review, written by U. Chiacchio, A. Padwa, and G. Romeo of Catania (Italy), Emory (USA), and Messina (Italy) Universities, respectively, includes 66 references and contains a representative sampling from the last 10 years on the syntheses of biologically active heterocycles using the 1,3-dipolar cycloaddition and Diels-Alder reactions. Some of these cycloadditions have been sequenced into a cascade process and the use of click chemistry have been also outlined. Using this methodology a wide variety of bio-compounds have been prepared such as aza-sugars, natural and modified nucleosides, ace inhibitors and different macromolecules containing the triazole ring. The many structures diverse and highly successful examples of heterocyclic ring formation indicated that cycloaddition methodology as evolved as an important strategy in heterocyclic synthesis. The second review, written by A. Rescifina and C. Zagni of Catania University, D. Iannazzo of Messina University and P. Merino of Zaragoza University deals with the recent progress occurred in the development of new and more functional molecular shuttles based on bistable [2]rotaxane chemistry covering the years 2006-2008, and includes 89 references. After a concise but exhaustive introduction on the utility and chemistry of this type of mechanically interlocked molecules, the paper prosecutes separately treating the three most important typologies of the energy inputs utilized to power their mechanical motions: chemical, photochemical and electrochemical ones. In each of these paragraphs, the authors described the synthesis, the working and the possible practical applications, in case they exist, of these intriguing systems. Regeneration of Carbonyl Compounds from the Corresponding Oximes: an Update Until to 2008, is the title of the third review written by A. Corsaro, M. A. Chiacchio and V. Pistara of Catania University. This work, which contains 221 references, is an update within the research progress in regeneration of carbonyl compounds from the corresponding oximes starting from 2001 until today and concerns deoximations of aldo- and keto-oximes under mild conventional conditions in aqueous and nonaqueous solution and under ultrasound, ultraviolet and microwave irradiation. Special importance has been given to heterogeneous and solvent-free reactions which, among their different peculiarities, were imperative with the increasing environmental concern that requires new eco-friendly reagents to be developed.

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/content/journals/coc/10.2174/138527209787582240
2009-03-01
2025-05-01
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  • Article Type:
    Research Article
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