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2000
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Volume 4, Issue 7
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

The structures, origins, biogenesis, synthesis and bioactivity of a selection of N-heterocyclic marine alkaloids are reviewed. The emphasis is on compounds poised as potential anticancer drugs: lamellarins (pyrroles), cephalostatins/ritterazines (pyrazines) and ecteinascidins (isoquinolines). Also discussed are examples of bioactive marine alkaloids that have emerged as novel leads. These include manzamines (beta-carbolines), variolins (pyridopyrrolopyrimidines) and the pyrroloquinoline family. This review emphasises the role of marine alkaloids as an important source of leads for drug discovery.

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/content/journals/coc/10.2174/1385272003376085
2000-07-01
2025-05-18

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  • Article Type:     Review Article
Keyword(s): Anticancer drugs; Beta carbolines; Bioactive marine alkaloids; Biogenesis; Cephalostatins; Didemnum chartaceum; Ecteinascidins; Isoquinolines; Lamellaria; Lamellarins; Lukianols; Manzamines; N-heterocyclic marine alkaloids; Ningalins; Pyrazines; Pyridopyrrolopyrimidines; Pyrrole alkaloids; Pyrroles; Pyrroloquinoline; Rigidin; Ritterazines; Storniamides; Tyrosine derived pyrrole alkaloids; Viriolins

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