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Volume 29, Issue 1
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

arylated heterocycles are a significant class of core scaffolds in medicinal chemistry, materials science, and agrochemistry, highlighting their importance in various fields. The development of innovative methodologies for synthesizing these fundamental structures has been a central focus in organic synthesis. Over the past few decades, numerous approaches have been established to synthesize -aryl heterocycles efficiently. Among these methods, the direct -arylation of N-H heterocycles stands out as one of the most straightforward and robust strategies for accessing -arylated heterocycles. This review provides a comprehensive review of the recent advances in the synthesis of -arylated heterocycles, encompassing the relevant literature from the past decade. The review summarizes the -arylation of N-H heterocycles using various catalytic systems, including palladium, nickel, copper, visible light-induced metal-catalyzed, and metal-free catalyzed methodologies. These advances highlighted the continuous evolution and optimization of synthetic strategies to create diverse and complex -arylated heterocycles, which are pivotal for furthering research and development in multiple scientific domains.

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2025-01-27

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/content/journals/coc/10.2174/0113852728320325240710053300
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Recent Advances in N-Arylation of Heterocycles in the Past Decade
Current Organic Chemistry 29, 41 (2025); https://doi.org/10.2174/0113852728320325240710053300
/content/journals/coc/10.2174/0113852728320325240710053300
/content/journals/coc/10.2174/0113852728320325240710053300
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  • Article Type:     Review Article
Keyword(s): aromatic heterocycles; Buchwald–Hartwig amination; Chan–Lam coupling; C–N coupling; N-arylation; transition-metal-catalyzed; Ullmann condensation

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