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Volume 29, Issue 3
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

In this paper, we present an efficient procedure for the transformation of a soybean phytosterol mixture into pregna-1,4,16-triene-3,20-dione, which is a key intermediate for the synthesis of valuable corticoids. The possibility of using two alternative methods for 1(2)-dehydrogenation of pregna-4,16-diene-3,20-dione-chemical and microbiological was shown. Microbiological 3-keto-4-ene steroid 1(2)-dehydrogenation was carried out using actinobacterial cells of VKM Ac-2033D. The structures of the synthesized compounds were confirmed by the IR, MS, and 1H-NMR and 13C-NMR methods.

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2024-08-27
2025-04-15

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/content/journals/coc/10.2174/0113852728317835240812102433
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Synthesis of Pregna-1,4,16-triene-3,20-dione from a Mixture of Soybean Phytosterols using a Combination of Chemical and Microbiological Methods
Current Organic Chemistry 29, 238 (2025); https://doi.org/10.2174/0113852728317835240812102433
/content/journals/coc/10.2174/0113852728317835240812102433
/content/journals/coc/10.2174/0113852728317835240812102433
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  • Article Type:     Research Article
Keyword(s): actinobacteria; androst-4-ene-3,17-dione; combined chemical-microbiological synthesis; phytosterol; Pregna-1,4,16-triene-3,20-dione; soybean phytosterol mixture

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