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Volume 28, Issue 20
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

We have created novel 1,2,3-triazole-based benzothiazinone derivatives in the current work. The produced compounds' antioxidant, antifungal, and antitubercular properties were assessed. Moreover, a simulated molecular docking analysis was conducted on the cytochrome P450 lanosterol 14α-demethylase active site to elucidate the enzyme's binding affinity and interactions with synthesised benzothiazinone derivatives. A notable correlation between these compounds' antifungal activity and binding score was indicated by molecular docking data. The synthetic 1,2,3-triazole-based benzothiazinone derivatives may satisfy the structural criteria for creating novel antifungal drugs, according to the results of the and investigations.

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2024-12-01
2025-04-12

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Synthesis and Biological Evaluation of 1,2,3-Triazole Appended Benzothiazinone Derivatives via Click Chemistry
Current Organic Chemistry 28, 1621 (2024); https://doi.org/10.2174/0113852728316869240626060258
/content/journals/coc/10.2174/0113852728316869240626060258
/content/journals/coc/10.2174/0113852728316869240626060258
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  • Article Type:     Research Article
Keyword(s): 1,2,3-Triazoles; ADME; antifungal activity; benzothiazinone; molecular docking; rifampicin

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