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Volume 29, Issue 7
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

A series of 4-thiazolidinone was synthesized and characterized by means of TLC, melting point, and spectral data like IR, 1H NMR, and Mass spectra. The anti-inflammatory activity of the synthesized compounds was determined studies. The antioxidant properties of the synthesized compounds were determined by carrageenan-induced rat paw edema model. The synthesized compounds showed significant anti-inflammatory and antioxidant activities. The most promising results for both antioxidant and anti-inflammatory activity were exhibited by compound which may emerge as a potent anti-inflammatory agent with potential free radical scavenging activity. Molecular docking studies were carried out to determine the interaction of compounds into the active site of COX-2 inhibitor (PDB ID: 3LN1), which suggested compound to have the best docking score by showing interactions with ASP483 and LYS478.

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2024-09-16
2025-05-23

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Exploring the Potential of Novel 4-thiazolidinone Derivatives as Dual Anti-inflammatory and Antioxidant Agents: Synthesis, Pharmacological Activity and Docking Analysis
Current Organic Chemistry 29, 580 (2025); https://doi.org/10.2174/0113852728301305240828073241
/content/journals/coc/10.2174/0113852728301305240828073241
/content/journals/coc/10.2174/0113852728301305240828073241
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  • Article Type:     Research Article
Keyword(s): 4-Thiazolidinone; anti-inflammatory; antioxidant; docking analysis; DPPH; pharmacological activity

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