Efficient Synthesis and Characterization of 6-substituted-N-p-tolyl-imidazo[1,2- a]pyridine-8-carboxamide: A Promising Scaffold for Drug Development

Imidazo[1,2-a]pyridine is a highly significant fused bicyclic heterocycle widely utilized in medicinal chemistry, and it holds a prominent position as a "drug prejudice" framework because of its extensive applications. Numerous approaches have been documented for the synthesis of imidazo[1,2-a]pyridines, with a particular focus on functionalizing these compounds. In this research, we have presented an effective multi-step synthesis method for producing imidazo[1,2-a]pyridines, achieving impressive yields ranging from 93% to 97%. The synthesized compounds were subjected to thorough characterization using various spectral analysis techniques, including FTIR, ¹H NMR, ¹³C NMR, mass spectrometry, and elemental analysis. Overall, this synthetic strategy possesses desirable features for the synthesis of imidazo[1,2-a]pyridines and their derivatives, including high product purity, accessible starting materials, broad substrate scope, scalability, and transformability. These characteristics make it a promising approach for further development and potential application in the synthesis of valuable therapeutic compounds.