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- Volume 22, Issue 3, 2023
CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders) - Volume 22, Issue 3, 2023
Volume 22, Issue 3, 2023
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Role of Unani Polyherbal Formulations in the Treatment of Diseases with Special Reference to Neurodegenerative Disorders
More LessUnani system of medicine is based on the use of natural plant products. Unani polyherbal formulations (UPFs) are being prescribed for the treatment of various ailments. The preparations of the UPFs also required the animal products such as honey and umber. UPFs have been reported to cure various diseases but still lack scientific credibility. The Unani system is based on the holistic approach; the synergistic role of the Read More
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The Role of Monoamine Oxidase B Inhibitors in the Treatment of Parkinson’s Disease - An Update
Authors: Zhi X. Chew, Chooi Ling Lim, Khuen Yen Ng, Soi Moi Chye, Anna P. K. Ling and Rhun Yian KohParkinson’s disease (PD) is a progressive neurodegenerative disease characterised by reduced dopamine levels in the substantial nigra. This may lead to typical motor features such as bradykinesia, resting tremors and rigid muscles, as well as non-motor symptoms such as neuropsychiatric symptoms, sleep disorders, autonomic dysfunction, and sensory disturbances. Inhibitors of monoamine oxidase B (MAO-B) are used to a Read More
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A Comprehensive Study of miRNAs in Parkinson’s Disease: Diagnostics and Therapeutic Approaches
Authors: Saima Owais and Yasir H. SiddiqueParkinson’s disease (PD) is the second most debilitating neurodegenerative movement disorder. It is characterized by the presence of fibrillar alpha-synuclein amassed in the neurons, known as Lewy bodies. Certain cellular and molecular events are involved, leading to the degeneration of dopaminergic neurons. However, the origin and implication of such events are still uncertain. Nevertheless, the role of microRNAs (miRN Read More
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An Updated Review of Epigenetic-Related Mechanisms and their Contribution to Multiple Sclerosis Disease
Multiple Sclerosis (MS) is a multifactorial, neurodegenerative, and inflammatory demyelination disease with incomplete remyelination in the CNS. It would be more informative to reveal the underlying molecular mechanisms of MS. Molecular mechanisms involving epigenetic changes play a pivotal role in this disease. Epigenetic changes impact gene expression without altering the underlying DNA sequence. The main epigene Read More
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Cenobamate: A Review of its Pharmacological Properties, Clinical Efficacy and Tolerability Profile in the Treatment of Epilepsy
Authors: Maria A. Barbieri, Emilio Perucca, Edoardo Spina, Paola Rota and Valentina FrancoCenobamate is a novel antiseizure medication (ASM) commercially available in Europe and in the U.S. for the treatment of focal seizures in adults. The mechanisms responsible for its antiseizure activity include enhancement of the inactivated state of voltage-gated sodium channels with blockade of the persistent sodium current and positive allosteric modulation of GABAA receptors at a non-benzodiazepine binding site. C Read More
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Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes
Authors: Sushma and Amal C. MondalBackground: Neurodegenerative diseases, being rapidly increasing disorders and the seventh leading cause of death worldwide, have been a great challenge for researchers, affecting cognition, motor activity and other body functioning due to neurodegeneration. Several neurodegenerative diseases are caused by aggregation of proteins which induce the alteration of neuronal function leading to cell death. These proteins ar Read More
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The Endocannabinoid System as a Biomarker for Diagnostic and Therapeutic Applications in Depression and Anxiety
Background: Depression and anxiety belong to a family of mental disturbances that have increased significantly in recent years. The etiology of both disorders comprises multiple and complex factors, from genetic background to environmental influence. Since depression and anxiety present severe symptoms, they represent a greater clinical burden and greater therapeutic difficulty. Currently, standardized diagnostic procedu Read More
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How Do Abnormalities in the Cerebrospinal Fluid Impact Neuropsychology with Progressing Age?
Authors: Gargi Joshi, Anna P. K. Ling, Soi M. Chye and Rhun Yian KohThe behavior of an individual changes from neonate to elderly due to the development of the central nervous system (CNS). One of the important components of the CNS is the cerebrospinal fluid (CSF), which bathes the brain and spinal cord. CSF has changing properties throughout life, including composition and volume imbalance. However, a specific age group that shows prevailing abnormality- corresponding behavior Read More
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Neuroprotective Potential of Bacopa monnieri: Modulation of Inflammatory Signals
Background: To date, much evidence has shown the increased interest in natural molecules and traditional herbal medicine as alternative bioactive compounds to fight many inflammatory conditions, both in relation to immunomodulation and in terms of their wound healing potential. Bacopa monnieri is a herb that is used in the Ayurvedic medicine tradition for its anti-inflammatory activity. Objective: In this study, we evaluate Read More
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Peripheral Vascular Disease is Associated with Impaired Activities of Daily Living in the Elderly with Dementia: A Prospective Study
Authors: Umut Safer, Mehmet I. Naharci, Ilker Tasci and Vildan Binay SaferBackground: Although distinct disorders, peripheral vascular disease (PVD) and dementia are both associated with a progressive decline in activities of daily living in elderly patients. Objective: This study aimed to compare the functional performance scores between elderly patients with and without dementia and with or without PVD. Methods: Patients with Alzheimer’s disease, vascular dementia, and mixed type dementia an Read More
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Volumes & issues
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Volume 24 (2025)
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Volume 23 (2024)
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Volume 22 (2023)
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Volume 21 (2022)
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Volume 20 (2021)
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Volume 19 (2020)
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Volume 18 (2019)
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Volume 17 (2018)
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Volume 16 (2017)
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Volume 15 (2016)
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Volume 14 (2015)
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Volume 13 (2014)
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Volume 12 (2013)
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Volume 11 (2012)
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Volume 10 (2011)
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Volume 9 (2010)
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Volume 8 (2009)
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Volume 7 (2008)
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Volume 6 (2007)
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Volume 5 (2006)
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A Retrospective, Multi-Center Cohort Study Evaluating the Severity- Related Effects of Cerebrolysin Treatment on Clinical Outcomes in Traumatic Brain Injury
Authors: Dafin F. Muresanu, Alexandru V. Ciurea, Radu M. Gorgan, Eva Gheorghita, Stefan I. Florian, Horatiu Stan, Alin Blaga, Nicolai Ianovici, Stefan M. Iencean, Dana Turliuc, Horia B. Davidescu, Cornel Mihalache, Felix M. Brehar, Anca . S. Mihaescu, Dinu C. Mardare, Aurelian Anghelescu, Carmen Chiparus, Magdalena Lapadat, Viorel Pruna, Dumitru Mohan, Constantin Costea, Daniel Costea, Claudiu Palade, Narcisa Bucur, Jesus Figueroa and Anton Alvarez
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