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Volume 21, Issue 3
  • ISSN: 1567-2026
  • E-ISSN: 1875-5739
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Abstract

Background

Neutrophil-To-Albumin Ratio (NAR) is a novel inflammatory biomarker. However, the potential prognostic value of NAR in acute ischemic stroke (AIS) remains unclear. This study aimed to evaluate whether NAR levels correlated with the 3-month modified Rankin scale (mRS) in patients with AIS.

Methods

AIS patients were included in this retrospective study. NAR was calculated as the ratio of absolute neutrophil count to serum albumin level. Logistic regression analyses were used to investigate the effect of NAR on 3-month mRS of AIS. The predictive values of NAR, albumin level, and neutrophil count were compared utilizing receiver operating characteristic (ROC) curves. Moreover, subgroup analyses and interaction tests were conducted to evaluate the consistency of NAR’s effect on AIS prognosis.

Results

Of the 780 patients included, 403 (51.67%) had a poor clinical outcome (mRS 3-6) at 3 months. NAR was independently correlated to 3-month poor functional outcome after adjusting for confounders (Odds ratios (OR), 9.34; 95% confidence intervals (CI), 1.09 to 80.13; =0.0417). Subgroup analysis showed a relative effect consistent with the overall population results, and no statistical interactions were found in the subgroups (all for interaction > 0.05). The ROC curve showed that the prognosis-related cutoff value for NAR was 0.123, with corresponding specificity and sensitivity of 53.55% and 63.94%, respectively. When comparing the predictive power, NAR (0.590; 95%CI 0.549–0.630) exhibited the highest area under the curve (AUC) of ROC compared to neutrophils (0.584; 95%CI 0.543–0.624) and albumin (0.540; 95%CI 0.500–0.581).

Conclusion

There is a positive relationship between NAR levels and 3-month poor functional outcomes in AIS patients, supporting the potential of NAR as a readily available and economic serum biomarker for the early identification of AIS prognosis. Further studies are required to validate the prognostic value and clinical utility of the NAR.

© 2024 Bentham Science Publishers
© 2024 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/cnr/10.2174/0115672026328594240614080241
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Neutrophil-to-albumin Ratio as a Prognostic Factor in Patients with Acute Ischemic Stroke
Curr Neurovasc Res 21, 300 (2024); https://doi.org/10.2174/0115672026328594240614080241
/content/journals/cnr/10.2174/0115672026328594240614080241
/content/journals/cnr/10.2174/0115672026328594240614080241
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  • Article Type:     Research Article
Keyword(s): AIS; inflammatory biomarker; NAR; Neutrophil-to-albumin ratio; prognosis; receiver operating characteristic; serum biomarker

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