A Review on the Importance of Annona muricata Crude Extract (AMCE) as a Nutraceutical Anti-Metastatic and its Coping Mechanism Against Breast Cancer

Background: Annona Muricata is used as a folkloric herbal medicine as it has anticancer, antiproliferative, and anti-tumorigenic properties. The extracts from various parts of the plant are considered therapeutic due to Annonaceous Acetogenin compounds which are an absolute boon to the versatility of the plant, paving the mechanistic pathways for its therapeutic potential. Methods: Google Scholar and PubMed databases were reviewed with the main focus on availing information on Annona muricata and its anticancer effect on breast cancer. Results and Discussion: An array of clinical investigations on the dosage of extracts on cell lines, animal models, and human trials provide confirmatory insights of A. muricata as a preventive and therapeutic measure for cancer. The extract, when administered at different dosages, shows a high cytotoxic effect on the cancer cells, mostly accounting for an IC50 of less than 1000μg/mL, which is of significance. Conclusion: Although high efficacy has been conclusive, assurance of safety prior to commercialization is of significance. Investigations are required to define the origin and magnitude of side effects along with long-term safety for the enhancement of efficacy and optimum utilization of potential chemopreventive properties of the plant for the development of a cancer nutraceutical intervention that outperforms traditional medicine.