Current Molecular Pharmacology - Volume 6, Issue 3, 2013

Transient receptor potential (TRP) channels are important candidates mediating Ca2+ influx in excitable and nonexcitable cells such as normal and neoplastic hematopoietic tissues. They are non selective cation channels implicated in Ca2+ signaling in hematologic tumor cells. Here, we review the growing experimental evidence indicating that TRP channels should be included among the genes whose expression is altered in he Read More

In humans, glucocorticoid excess may cause neuropsychiatric symptoms, including psychosis and cognitive impairment, and glucocorticoid signaling hyperactivation may sensitize to substance of abuse. The aim of this work was to evaluate whether exposure to glucocorticoid excess triggers molecular changes in dopaminergic and opioidergic systems within relevant forebrain areas. We acutely exposed Sprague-Dawl Read More

The aim of the study was to determine the allele and genotype frequencies of rs1532624 SNP of the cholesteryl ester transfer protein gene (CETP) among 116 Jordanian patients taking statins, and to study the impact of the genotypes on response to statin therapy. The study was approved by the Institutional review Board (IRB) of The Jordan University Hospital. An informed consent was signed by every participant. A single frag Read More

Bisphenol A (BPA), the highest volume chemical produced in the whole world is widely used in the production of polycarbonate plastics and epoxy resins. Polycarbonate plastics are used especially in the manufacture of consumer products. The exposure of BPA to humans occurs through food contamination from polycarbonate bottles and food and beverage cans. Dust is also a contributor to the total daily exposure of BPA. Thu Read More

Transcription factors (TFs) orchestrate multiple cellular processes through tight regulation via post-translational modifications (PTMs). Thus, decoding the combinations of PTMs should provide critical layer of information that can be integrated into highly specific cellular outputs to reveal a network of genes and their target-specific regulation. Protein modifications play a decisive role in various drug responses and eventually Read More

The cannabinoid receptor CB2 is highly expressed in immune cells suggesting an important role in numerous diseases such as inflammation, cancer, osteoporosis and liver diseases relating to modulation of the immune system. As a consequence, activation of receptor CB2 is a promising therapeutic strategy for the treatment of a large range of diseases. Indeed, selective CB2 agonists display beneficial anti-inflammatory, Read More

Hypoxia has been reported to regulate both stem cell maintenance and differentiation. Wnt signaling is also a key regulator in stem cells. The recent discovery of functional cross-regulation between the Wnt pathway and HIF- 1α/HIF-2α signaling further highlights the complexity of the role of hypoxia in the regulation of stem cells. In this report we reveal that human CML cell lines treated under hypoxic conditions increase th Read More