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Volume 24, Issue 11
  • ISSN: 1566-5240
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Abstract

Background

Several signaling pathways are involved in the process of angiogenesis, which is one of the most important hallmarks of glioblastoma multiforme (GBM). Identifying related gene variants can help researchers work out what causes anti-angiogenesis drug resistance.

Objective

The goal of this systematic analysis was to identify all mutations and polymorphisms involved in angiogenesis pathways in GBM and their impact on clinical outcomes.

Methods

The keywords include glioblastoma, angiogenesis, signaling pathway, mutation, polymorphism, and related terms used to search ISI, PubMed, and Scopus for relevant articles published up to January 2022. The PRISMA protocol was used to conduct our systematic review. The related articles were taken into consideration. The risk of bias in the associated articles was surveyed, as well as the article scoring. Two authors collaborated on data extraction.

Results

The inclusion criteria were included in 32 articles out of a total of 787 articles. , , , , and are the pathways that have been studied the most. , , , and HIF1a are the genes with the highest frequency of mutations or polymorphisms.

Conclusion

In conclusion, this study found that angiogenesis in primary or recurrent GBM is linked to gene changes in eleven signaling pathways. However, some of these gene mutations have been researched numerous times in relation to angiogenesis, while others have only been studied once. Understanding these changes will help us employ combination therapies more effectively for GBM patients' survival and personal medicine.

© 2024 Bentham Science Publishers
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2023-10-04
2024-11-26

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Genetic Variants Impacting Angiogenesis Signaling Pathways in Glioblastoma Multiforme: A Systematic Review of Mutations and Polymorphisms
Current Molecular Medicine 24, 1346 (2024); https://doi.org/10.2174/1566524023666230725115812
/content/journals/cmm/10.2174/1566524023666230725115812
/content/journals/cmm/10.2174/1566524023666230725115812
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  • Article Type:     Review Article
Keyword(s): angiogenesis; glioblastoma multiforme; Mutation; polymorphism; signaling pathway; VEGF

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