Full text loading...
- ISSN: 1566-5240
- E-ISSN: 1875-5666
-
Sumoylation in Cellular Senescence and Aging
- Source: Current Molecular Medicine, Volume 16, Issue 10, Dec 2016, p. 871 - 876
-
- 01 Dec 2016
Abstract
Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.
© Bentham Science Publishers