Skip to content
2000
Volume 14, Issue 2
  • ISSN: 1566-5240
  • E-ISSN: 1875-5666

Abstract

The low molecular weight GTP-binding protein RhoA regulates many cellular events, including cell migration, organization of the cytoskeleton, cell adhesion, progress through the cell cycle and gene expression. Physical forces influence these cellular processes in part by regulating RhoA activity through mechanotransduction of cell adhesion molecules (e.g. integrins, cadherins, Ig superfamily molecules). RhoA activity is regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) that are themselves regulated by many different signaling pathways. Significantly, the engagement of many cell adhesion molecules can affect RhoA activity in both positive and negative ways. In this brief review, we consider how RhoA activity is regulated downstream from cell adhesion molecules and mechanical force. Finally, we highlight the importance of mechanotransduction signaling to RhoA in normal cell biology as well as in certain pathological states.

Loading

Article metrics loading...

/content/journals/cmm/10.2174/1566524014666140128104541
2014-02-01
2025-06-01
Loading full text...

Full text loading...

/content/journals/cmm/10.2174/1566524014666140128104541
Loading

  • Article Type:
    Research Article
Keyword(s): Actin; adhesion; cytoskeleton; force; GTPase; mechanotransduction; RhoA
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test