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Volume 24, Issue 11
  • ISSN: 1566-5240
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Abstract

Background

Some tumors have a poor prognosis regarding TPD52 (tumor protein D52). This study aims to explore TPD52's role in the cancer process from a pan-cancer perspective.

Methods

A pan-cancer analysis was conducted to investigate how TPD52 may be involved in cancer as well as its association with prognosis.

Results

A variety of human cancers express TPD52 abnormally and correlate with clinical stage. There was a significant association between low expression of TPD52 and poor survival in BRCA, KIRP, LAML, LIHC, UCEC, and UVM. TPD52 alterations were most frequently amplified in pan-cancer. The co-occurrence of 10 genes alterations was found in the TPD52 altered group. There was a significant association between TPD52 expression and MSI in four cancer types and TMB in twelve cancer types. There was a significant correlation between TPD52 expression and immune-related cell infiltration. A significant correlation was found between TPD52 expression in many tumor types and 8 immune checkpoint genes. There were signaling pathways involved in pan-cancer caused by TPD52, including endocytosis, Fc gamma R-mediated phagocytosis, and so on. TPD52 may be involved in chemotherapy and chemoresistance.

Conclusion

The TPD52 gene may be important for human cancer treatment.

© 2024 Bentham Science Publishers
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2023-10-16
2024-11-30

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/content/journals/cmm/10.2174/0115665240260252230919054858
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TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis
Current Molecular Medicine 24, 1413 (2024); https://doi.org/10.2174/0115665240260252230919054858
/content/journals/cmm/10.2174/0115665240260252230919054858
/content/journals/cmm/10.2174/0115665240260252230919054858
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  • Article Type:     Research Article
Keyword(s): drug sensitivity; genomic alteration; immune infiltration; Pan cáncer; prognosis; TPD52

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