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Volume 24, Issue 12
  • ISSN: 1566-5240
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Abstract

Background

3-Amino-4-(2,4,5-trifluorophenyl) butyric acid has potential pharmacological effects in promoting insulin secretion. Menthol promotes drug transdermal absorption and hypoglycemic effects.

Objective

The objective of the study was to combine the 3-amino-4-(2,4,5-trifluorophenyl) butyric acid and menthol to develop a new candidate drug molecule that can be used as a hypoglycemic drug in type II diabetes.

Methods

In this study, the molecular structure of 3-amino-4-(2,4,5-trifluorophenyl) butyric acid in sitagliptin was modified by replacing pyrazine imidazole with menthol. The structure of the target compound was characterized by nuclear magnetic resonance (NMR). The anti-diabetic activity of BHF in N000180 BKS.Cg-Dock7m+/ +Leprdb/Nju mice with spontaneous diabetes was preliminarily studied.

Results

A potential multi-target drug molecule, 3-amino-4-(2,4,5-trifluorophenyl) butyrate (BHF), was synthesized by combining 3-amino-4-(2,4,5-trifluorophenyl) butyric acid and menthol. BHF is suitable for hyperglycemic mice and has a significant hypoglycemic effect; the low dose of 10 mg/kg-1 started to be effective, and the high dose of 40 mg/kg-1 was more effective than the positive drug metformin.

Conclusion

In this study, BHF has been synthesized and presented significant antidiabetic activities.

© 2024 Bentham Science Publishers
© 2024 The Author(s). Published by Bentham Science Publishers. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2024-12-01
2024-11-26

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Preparation of Menthyl 3-amino-4-(2,4,5-trifluorophenyl) Butyrate and Investigation of its Hypoglycemic Activity
Current Molecular Medicine 24, 1550 (2024); https://doi.org/10.2174/0115665240256416231120105956
/content/journals/cmm/10.2174/0115665240256416231120105956
/content/journals/cmm/10.2174/0115665240256416231120105956
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Supplements

Supplementary data [1H NMR and 13C NMR spectra of menthyl 3-amino-4-(2, 4, 5-trifluorophenyl) butyrate] are available free of charge at http://jbcs.sbq.org.br as PDF file.

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  • Article Type:     Research Article
Keyword(s): 3-amino-4-(2,4,5-trifluorophenyl)butyrate; bioactivity; diabetes; hypoglycemic activity; menthol; sitagliptin analog

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