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- ISSN: 2213-3356
- E-ISSN: 2213-3364
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Solvent and Catalyst Free, Regioselective α-Bromination of Aralkyl Ketones Using N-Bromosuccinimide (NBS) Under Microwave Irradiation: An Efficient Protocol
- Source: Current Microwave Chemistry, Volume 2, Issue 1, Apr 2015, p. 61 - 68
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- 01 Apr 2015
Abstract
An exceptionally efficient, environmentally safe and economic method has been developed for regioselective α-bromination of various aralkyl ketones in excellent yield with N-bromosuccinimide (NBS) under microwave irradiation (CEM discover) without use of either a solvent or a catalyst. After completion of the reaction, the NBS can be regenerated by using an environment friendly brominating agent NaBr/NaBrO3 in acetic acid. The present procedure offers various advantages such as a very short reaction time, simple work-up procedure, excellent yield of products and recovery of the reagents by green protocol.
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