Current Molecular Imaging (Discontinued) - Volume 4, Issue 1, 2015

The use of 2-deoxy-2-[18F] fluoro-D-glucose (FDG) and positron emission tomography/ computed tomography (PET/CT) is increasing rapidly – and the list of emerging and evolving applications is everexpanding in a multitude of clinical settings. In this anniversary review celebrating four decades of FDG, we will outline an overview of the present status of FDG imaging with emphasis on clinical implementation in the main i Read More

Background: Tc-99m labeled Glucaric Acid (Tc-GA) and In-111 labeled human fibrinogen (In-HF) were used to demonstrate reduction in myocardial infarction and microvascular injury in rabbit preconditioned ischemic hearts. Methods: New Zealand White rabbits were subjected to preconditioning or non-preconditioning ischemic myocardial injury. Reperfusion was established after 45 min of circumflex occlusion and Read More

A protocol to load perfluoro-crown-ether (PFCE) nanoemulsion directly into yeast-derived glucan particles (GPs) was developed. It was observed that the PFCE encapsulation did not affect the 19F-MRI properties of the nanoemulsion that is currently in clinical trials. GPs loaded with PFCE nanoemulsion were taken up avidly by murine macrophages in vitro, resulting in a cellular uptake 150 % higher than the not GPs-entrap Read More

Purpose: The unambiguous prostate cancer diagnosis is of high global interest. Magnetic Resonance Imaging (MRI) is a low invasive modality in early stages of tumor diagnosis, especially for cancer detection. The study aim is to synthesize Gd3+ based silica mesoporous nanosphere conjugated with Monoclonal Antibody (Mab C595) and evaluate its ability as nanoprobe for prostate cancer cells detection. Method: Here Read More

Cocaine has been known to inhibit dopaminergic and serotonergic systems. Here, we aimed to study the addictive effects of cocaine on both systems of rats after chronic treatments. Rats were treated with vehicle or cocaine for four months, and the changes of behavior and expressions and activity of dopaminergic and serotonergic systems were assessed. Locomotion was used to estimate the animal behavior. The neur Read More

Translational projects frequently test agents by intravenous injection into small animals. One problem is that it is usually uncertain exactly how successful each injection is at time of administration. This leads to high variation in measurements and necessitates the use of larger groups of animals. To circumvent this problem, we introduce a novel near infrared imaging method to determine injection success in adult and ne Read More

Background: Post-Traumatic Stress Disorder (PTSD) is an anxiety disorder in response to a major traumatic event. Higher levels of trauma may be associated with more deficits in the brain SERT availability. We investigated the in vivo dynamitic change of SERT availability in the brain of PTSD rat with increasing severity of disease with 4-[18F] ADAM PET which reflects the SERT availability. Methods: Pavlovian fear conditioning mod Read More