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2000
Volume 4, Issue 1
  • ISSN: 2211-5552
  • E-ISSN: 2211-5544

Abstract

A protocol to load perfluoro-crown-ether (PFCE) nanoemulsion directly into yeast-derived glucan particles (GPs) was developed. It was observed that the PFCE encapsulation did not affect the 19F-MRI properties of the nanoemulsion that is currently in clinical trials. GPs loaded with PFCE nanoemulsion were taken up avidly by murine macrophages in vitro, resulting in a cellular uptake 150 % higher than the not GPs-entrapped nanoemulsion. Accordingly, a corresponding improvement in the 19F-MRI detection of the labelled cells can be obtained. The high biotolerability and versatility of GPs, make these microcarriers a promising option for designing of improved in vivo cellular imaging protocols.

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/content/journals/cmi/10.2174/2211555204666150702160805
2015-04-01
2025-06-12
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/content/journals/cmi/10.2174/2211555204666150702160805
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  • Article Type:
    Research Article
Keyword(s): 19F-MRI; cellular imaging; glucan particles; macrophages; perfluorocarbons; theranosis
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