Skip to content
2000
Volume 31, Issue 12
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Introduction: Angiogenesis involves the development of new blood vessels. Biochemical signals start this process in the body, which is followed by migration, growth, and differentiation of endothelial cells that line the inside wall of blood vessels. This process is vital for the growth of cancer cells and tumors. Materials and Methods: We started our analysis by composing a list of genes that have a validated impact in humans with respect to angiogenesis-related phenotypes. Here, we have investigated the expression patterns of angiogenesis-related genes in the context of previously published single-cell RNA-Seq data from prostate and breast cancer samples. Results: Using a protein-protein interaction network, we showed how different modules of angiogenesis-related genes are overexpressed in different cell types. In our results, genes, such as ACKR1, AQP1, and EGR1, showed a strong cell type-dependent overexpression pattern in the two investigated cancer types, which can potentially be helpful in the diagnosis and follow-up of patients with prostate and breast cancer. Conclusion: Our work demonstrates how different biological processes in distinct cell types contribute to the angiogenesis process, which can provide clues regarding the potential application of targeted inhibition of the angiogenesis process

Loading

Article metrics loading...

/content/journals/cmc/10.2174/0929867330666230331101458
2024-04-01
2025-07-14
Loading full text...

Full text loading...

/content/journals/cmc/10.2174/0929867330666230331101458
Loading

  • Article Type:
    Research Article
Keyword(s): ACKR1; Angiogenesis; breast cancer; EGR1; prostate cancer; systems biology
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test