Skip to content
2000
Volume 29, Issue 13
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Doublecortin-like kinase 1 (DCLK1) has emerged over the last decade as a unique stem cell marker within gastrointestinal tissues. Evidence from mouse models shows that high Dclk1 expression denotes a population of cells that promote tissue regeneration and serve as potential cancer stem cells. Moreover, since certain DCLK1 isoforms are overexpressed in many cancers and not normal cells, targeting the expression or kinase activity of DCLK1 has the potential to inhibit cancer cell growth. Here, we review the evidence for DCLK1 as a prospective cancer target including its isoform-specific expression and mutational status in human cancers. We further discuss the challenges and current progress in the development of small molecule inhibitors of DCLK1.

Loading

Article metrics loading...

/content/journals/cmc/10.2174/0929867328666210709110721
2022-04-01
2024-12-24
Loading full text...

Full text loading...

/content/journals/cmc/10.2174/0929867328666210709110721
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test