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Cell-to-Cell Transmission of the Unfolded Protein Response - Is it a Real Phenomenon?
- Source: Current Medicinal Chemistry, Volume 28, Issue 22, Jul 2021, p. 4586 - 4587
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- 01 Jul 2021
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Abstract
Cell-to-cell transmission of the unfolded protein response (UPR) is one of the most exciting observations recently made in cell biology. One of the most efficient tools to induce UPR response in cell culture is treatment with specific compounds leading to accumulation of misfolded proteins in endoplasmic reticulum. In this article we discussed opposite opinions regarding application of this approach and possible sources of experimental artefacts.
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