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2000
Volume 22, Issue 15
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Necrosis is an in vivo chaotic event distinguished by uncontrolled disintegration of the cell membrane leading to cytolysis, inflammation and tissue destruction followed by a healing or regenerating process. Targeting necrosis may offer potential diagnostic, therapeutic and/or theragnostic applications in translational medicine. This article reviews the current concept of necrosis including definition, etiology and pathophysiology. The evolution and development of a wide diversity of necrosis targeting agents and their potential applications in preclinical and clinical settings are also elaborated and discussed.

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/content/journals/cmc/10.2174/0929867322666150227153550
2015-05-01
2025-05-09
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/content/journals/cmc/10.2174/0929867322666150227153550
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  • Article Type:
    Research Article
Keyword(s): Cancer; cardiovascular diseases; diagnosis; necrosis; necrosis avid compounds; treatment
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