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2000
Volume 22, Issue 10
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.

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/content/journals/cmc/10.2174/0929867322666150209153606
2015-04-01
2024-12-24
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/content/journals/cmc/10.2174/0929867322666150209153606
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  • Article Type:
    Research Article
Keyword(s): Granulocyte-colony stimulating factor; neuroprotection; stroke; treatment
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