Skip to content
2000
Volume 20, Issue 26
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

To study novel treatments for high grade gliomas (WHO grade III and IV) we need animal models of those disorders. Orthotopic tumors in mouse or rats seem at present the most reliable in vivo glioma model in order to develop specific therapies. The orthotopic tumor characteristics should yet closely mimic the human glioma features (in particular infiltrating growth and neovascularization). In this regard, glioma cell lines with stem properties (glioma stem cells – GSC) may fulfill at best those needs. Orthotopic gliomas developed from some widely used, established non-stem cell lines showing poor infiltrating capacity are not suitable. Therapeutic and diagnostic procedures recently developed using orthotopic rodent glioma tumors along their potentialities and pitfalls are analyzed.

Loading

Article metrics loading...

/content/journals/cmc/10.2174/0929867311320260011
2013-09-01
2025-01-17
Loading full text...

Full text loading...

/content/journals/cmc/10.2174/0929867311320260011
Loading

  • Article Type:
    Research Article
Keyword(s): Brain tumor; cell cycle; glioblastoma; radiotherapy; resistance and in vivo; temozolomide
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test