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2000
Volume 19, Issue 34
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Influenza is an infection of the upper respiratory tract caused by influenza virus. Neuraminidase (NA) plays an essential role in replication and infection of influenza virus. It is considered as a suitable target for antivirus agents development. Several potent NA inhibitors (NAIs) developed by using structure-based rational design have been widely used in clinic for treatment of influenza. However, the emergence of NA inhibitor-resistant virus mutations significantly limit their effectiveness. The molecular basis of virus resistance to NAIs has been a focus of intensive research. This review highlights recent progress in rational design and resistance mechanism of NAIs. We hope this review will be useful to not only researchers who are interested in developing novel NAIs but also clinical pharmacists.

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/content/journals/cmc/10.2174/092986712804143358
2012-12-01
2025-02-21
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/content/journals/cmc/10.2174/092986712804143358
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  • Article Type:
    Research Article
Keyword(s): anti-influenza agents; computer-aided drug design; Neuraminidase (NA); resistance
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