Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Medicinal Chemistry
  4. Volume 18, Issue 4
  5. Article
Volume 18, Issue 4
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Aurora B is a serine-threonine kinase belonging to the highly conserved Aurora family of mitotic kinases. Aurora B is a chromosomal passenger protein involved in chromosome segregation, spindle-checkpoint, and cytokinesis. Alteration of each of these steps could induce aneuploidy, one of main features, and driving force of cancer progression. The overexpression of Aurora B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. In this review we will focus on the role of Aurora B in cancer development, its role as a prognostic marker, and the clinical outcome of recently developed Aurora(s) inhibitors.

© Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cmc/10.2174/092986711794480203
2011-02-01
2025-05-07

  • From This Site

    /content/journals/cmc/10.2174/092986711794480203
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

/content/journals/cmc/10.2174/092986711794480203
Loading

  • Article Type:     Research Article
Keyword(s): acute lymphocytic leukemia; anaphase-promoting complex; aneuploidy; Aurora B; Aurora Inhibitors; Aurora kinase; Benzimidazoles; C. elegans; cancer; carcinoma; centrosome; chromosome; chronic mye-loid leukemia (CML); colon; Cromosomal Passenger Complex; cytokinesis; Cytokinesis Kinase; Drosophila; glioblastoma; hepatocellular carcinoma; HESPERADIN; Histone Kinase; indolinone; inhibitors; INner CENtromere Pro-tein (INCENP); kinetochores; malignant en-dometrium; mesothelioma; Mi-totic Centromere-Associated Kinesin; microtubule-depolymerizing kinesin MCAK; mitosis; neoplastic lesions; oral cancer; phosphorylation; Prognostic Marker; prometaphase; prostate; S. pombe; Saccharomyces cerevisiae; serine-threonine kinase; Spindle Checkpoint Kinase; Survivin; testicular germ; Testis Zinc Finger Protein (Tzfp); Tetrahymena thermophila; Therapeutic Target; thyroid; Xenopus

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test