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Volume 17, Issue 30
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Estrogen-dependent breast cancer (EDBC) is a kind of common malignant tumor in postmenopausal women with growing tendency in recent years. Aromatase (AR) is the key enzyme responsible for estrogen biosynthesis and has been considered as an important target for designing inhibitors as potent therapeutic agents for EDBC. AR inhibitors (AIs) are divided into steroidal and nonsteroidal compounds, and the latter shows high inhibitory potency against AR. This review summarizes recent advancement in nonsteroidal AIs.

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/content/journals/cmc/10.2174/092986710792927877
2010-10-01
2025-05-11

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  • Article Type:     Research Article
Keyword(s): (EGFR) HER-2; aminoglutethimide; aromatase; Aromatase (AR); aromatase (AR); Aromatase inhibitors; aromatase inhibitors; breast adipose stromal; C19 androgenic; celecoxib; cellular transformation; COX-2; CYP19; Dual Aromatase-Sulfatase Inhibitors; endocrine therapy; Estrogen receptor; Estrogen-dependent breast cancer; Estrone 3-sulfamate (EMATE); flavanone; glycosylated cytochrome P450; granulosa; imidazolic; inflammatory cytokines; inhibitory potency; Isoflavones; letrozole, anastrozole; liquiritigenin; long-term tamoxifen treatment; luteal cells; mammary tumors; multienzymatic complex; Nimesulide Analogues; nonsteroida; nonsteroidal; Nonsteroidal Aromatase Inhibitors; oncogenesis; ovarian granulosa cells; peripheral tissues; PGE2; postmenopausal women; prostaglandin E2 (PGE2); prostate cancer; pyridinecontaining (E)-isomer; therapeutic agents; tolerability; traditional Chinese medicine; YM511

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