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- ISSN: 0929-8673
- E-ISSN: 1875-533X
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Post-assembly Peptide Modifications by Chemical Methods
- Source: Current Medicinal Chemistry, Volume 12, Issue 7, Apr 2005, p. 849 - 875
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- 01 Apr 2005
Abstract
The demand for peptide drugs is increasing and in this context, “post-assembly (or posttranslational) peptide modification strategies” by chemical manipulation of intact oligo-peptides has provided several analogues. Compounds prepared by this method are useful therapeutic molecules for structure activity studies. Herein, we describe various chemical methods such as cross-coupling reactions, cycloaddition reactions, radical reactions and ring-closing metathesis reactions that are useful for posttranslational peptide modifications.
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