Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design

Lidia M. Lima; Eliezer J. Barreiro

doi:10.2174/0929867053363540

ISSN: 0929-8673
E-ISSN: 1875-533X

Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design
Authors: Lidia M. Lima¹ and Eliezer J. Barreiro²
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¹ Laboratorio de Avaliacao e Sintese de Substancias Bioativas (LASSBio), Faculdade de Farmacia, Universidade Federal do Rio de Janeiro. CCS, Cidade Universitaria, CP 68.006, 21944-190, Rio de Janeiro, R.J., Brazil. ² Laboratorio de Avaliacao e Sintese de Substancias Bioativas (LASSBio), Faculdade de Farmacia, Universidade Federal do Rio de Janeiro. CCS, Cidade Universitaria, CP 68.006, 21944-190, Rio de Janeiro, R.J., Brazil.
Source: Current Medicinal Chemistry, Volume 12, Issue 1, Jan 2005, p. 23 - 49
DOI: https://doi.org/10.2174/0929867053363540
- Available online: 01 Jan 2005

Abstract

This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds.

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2005-01-01

2025-05-05

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Article Type: Review Article

Keyword(s): antagonist; hplc; isosterism; lead compound; pharmacodynamic; pharmacokinetic; prostaglandin-h synthase-2 (pghs-

Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design

Abstract

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