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2000
Volume 11, Issue 2
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

α-Galactosylceramide (α-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. γ-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-α and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of α- GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of α-GalCer and its possible future application for clinical studies in humans.

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/content/journals/cmc/10.2174/0929867043456115
2004-01-01
2025-03-17
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/content/journals/cmc/10.2174/0929867043456115
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  • Article Type:
    Review Article
Keyword(s): Galactosylceramide; GalCer; immunomodulatory
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