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- ISSN: 0929-8673
- E-ISSN: 1875-533X
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Design and Development of Integrase Inhibitors as Anti-HIV Agents
- Source: Current Medicinal Chemistry, Volume 10, Issue 18, Sep 2003, p. 1779 - 1794
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- 01 Sep 2003
Abstract
A review is presented on different categories of compounds that have been studied for the inhibition of the HIV-1 integrase to develop anti-HIV agents. These compounds are: oligonucleotides (double-stranded, triplex, and G-quartet), curcumin analogues, polyhydroxylated aromatic compounds, diketo acids, caffeoyl- and galloyl - based compounds, hydrazides and amides, tetracyclines, and depsides and depsidones. For all these compounds, the important structural features essential for the inhibition of the integrase are pointed out.
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