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- ISSN: 0929-8673
- E-ISSN: 1875-533X
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Neurotransmission and Neurotoxicity by Nitric Oxide, Catecholamines, and Glutamate: Unifying Themes of Reactive Oxygen Species and Electron Transfer
- Source: Current Medicinal Chemistry, Volume 10, Issue 24, Dec 2003, p. 2693 - 2703
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- 01 Dec 2003
Abstract
This review treats the mechanism of nitric oxide, catecholamines, and glutamate as important neurotransmitters and as neurotoxins, based on involvement of reactive oxygen species (ROS) and electron transfer (ET). ROS and ET can serve as a unifying framework for both transmission and toxicity, with ROS concentration being a crucial issue. Cell signaling, electrochemistry, antioxidants, and apoptosis are also discussed.
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