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- ISSN: 0929-8673
- E-ISSN: 1875-533X
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Development of DNA Topoisomerase II-Mediated Anticancer Agents, 3-(9- Acridinylamino)-5-hydroxymethylanilines (AHMAs) and Related Compounds
- Source: Current Medicinal Chemistry, Volume 9, Issue 18, Sep 2002, p. 1677 - 1688
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- 01 Sep 2002
Abstract
A series of potential topoisomerase II-mediated anticancer 9-anilinoacridine derivatives, which are designed to avoid bio-oxidation and possessed long duration of drug action, is reviewed. Among these agents, 3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives and their alkylcarbamates have been investigated and developed for potential clinical application.
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