Skip to content
2000
Volume 9, Issue 22
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

As the first recognized member of the “okadaic acid class” of phosphatase inhibitors, the marine natural product okadaic acid is perhaps the most well-known member of a diverse array of secondary metabolites that have emerged as valuable probes for studying the roles of various cellular protein serine / threonine phosphatases. This review provides a historical perspective on the role that okadaic acid has played in stimulating a broad spectrum of modern scientific research as a result of the natural product's ability to bind to and inhibit important classes of protein serine / threonine phosphatases. The relationships between the structure and biological activities of okadaic acid are briefly reviewed, as well as the structural information regarding the particular cellular receptors protein phosphatases 1 (PP1) and 2A. Laboratory syntheses of okadaic acid and its analogs are thoroughly reviewed. Finally, an interpretation of the critical contacts observed between okadaic acid and PP1 by X-ray crystallography is provided, and specific molecular recognition hypotheses that are testable via the synthesis and assay of non-natural analogs of okadaic acid are suggested.

Loading

Article metrics loading...

/content/journals/cmc/10.2174/0929867023368791
2002-11-01
2025-05-05
Loading full text...

Full text loading...

/content/journals/cmc/10.2174/0929867023368791
Loading

  • Article Type:
    Review Article
Keyword(s): crystallography; Okadaic Acid; threonine phosphatases
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test