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image of Oridonin Suppresses the Malignant Progression of Lung Cancer by Targeting S100A11

Abstract

Background

Lung cancer (LC) is the second most lethal cancer and efficient treatments are missing. Our understanding of the underlying pathogenic mechanisms remains limited. Oridonin is a compound extracted from the Chinese herb with anticancer properties. Nevertheless, its effects on LC and the underlying mechanisms remain unknown.

Methods

In the current research, A549 and Hcc1833 cells were treated with different doses of oridonin, and cell proliferation and migration were detected using CCK8, EdU, Transwell, and wound healing assays. A subcutaneous tumor and caudal vein metastasis model was generated to verify the inhibitory effects of oridonin on Hcc1833 tumor growth and metastasis . Proteomics analyses then were performed to examine the regulatory mechanism. LiP-SMap combined with microscale thermophoresis and molecular docking analyses were used to validate the relationship between oridonin and S100A11.

Result

Data showed that oridonin suppressed cell proliferation and migration depending on dose and suppressed tumor growth and invasion. LiP-SMap and molecular docking analyses confirmed that oridonin interacted with the Asn-53 residue of S100A11, which inhibited the activation of oridonin. S100A11 overexpression reversed the inhibitory effects of oridonin on cell proliferation and migration.

Conclusion

In conclusion, the data indicate that oridonin suppresses LC malignant progression by targeting S100A11.

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2025-01-23
2025-07-23

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Oridonin Suppresses the Malignant Progression of Lung Cancer by Targeting S100A11
Bentham Science Publishers ; https://doi.org/10.2174/0109298673352893241228015939
/content/journals/cmc/10.2174/0109298673352893241228015939
/content/journals/cmc/10.2174/0109298673352893241228015939
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  • Article Type:     Research Article
Keywords: S100A11 ; malignant progression ; lung cancer ; Oridoninm

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