Current HIV Research - Volume 15, Issue 5, 2017

Background: Although HIV and injury contribute substantially to disease burdens in lowand middle-income countries (LMIC), their intersection is poorly characterized. Objective: This systematic review assessed the prevalence and associated mortality impact of HIVseropositivity among injured patients in LMIC. Methods: A systematic search of PubMed, EMBASE, Global Health, CINAHL, POPLINE and Cochrane databases th Read More

Background: Natural variability of integrase (IN) across HIV-1 variants may influence the emergence of resistant viruses. The most apparent explanation of this fact is the IN polymorphism and the associated differences in codon usage, which in turn, influence the probability and the terms of DRMs acquisition. Possible mechanisms by which polymorphisms affect DRMs emergence remain disputed and should still be clarified Read More

Introduction: With advances in proteomics, it is essential to investigate the molecularlevel participation of IL27 and gp130 to hinder HIV infection. Their interaction causes cell-cycle arrest in HIV+ cells by activating the receptor-associated JAK signaling and causing apoptosis of cancerous cells. Methodology: The best human wild-type WT_IL27 model was prepared after varied molecular modeling techniques. The vital tyrosine re Read More

Background: The role of vitamin D in the pathophysiology of human immunodeficiency virus type 1 (HIV-1) infection is still unclear. Objective: To evaluate the associations between vitamin D and immunological, virological, and oxidative stress biomarkers in individuals with human immunodeficiency virus type 1 (HIV-1) infection. Methods: The serum levels of 25 hydroxyvitamin D [25(OH)D] were determined in 314 Read More

Background: The impact of protein intake level leads to considerable alterations of the host essential amino acid profiles in the context of chronic viral infectious process. Amino acids play an important role in the pathogenesis of virus-related infections both as basic substrates for constant protein synthesis and as regulators in many metabolic pathways. The excess or deficiency of these host essential nutritional elements c Read More

Background: Raltegravir (RAL) is considered one of the better-tolerated antiretroviral medications, due to limited side effects and minimal drug-drug interactions. Matherials and Methods: We retrospectively evaluated 96 HIV+, over 60 years old, experienced patients who had switched from any antiretroviral drug to raltegravir-based nuc-sparing or standard nucleoside-backbone regimens. A control group with patients aged Read More

Background: Relatively little attention has been paid to the significant HIV prevention role that voluntary medical male circumcision (VMMC) can play in populations with moderate levels of HIV prevalence. One such location is Tanah Papua, Indonesia, which in 2013 had a general population having HIV prevalence of 2.3% concentrated among indigenous Papuans (2.9% prevalence), very few of whom are circumcised. This art Read More

Background: Healthcare settings screen broadly for HIV. Public health settings use social network and partner testing (“Transmission Network Targeting (TNT)”) to select high-risk individuals based on their contacts. HIV screening and TNT systems are not integrated, and healthcare settings have not implemented TNT. Objective: The study aimed to evaluate pilot implementation of multi-component, multi-venue TNT in conjun Read More